The Ultimate American Adventure
Cruise historic waterways and awe-inspiring coastlines
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7 Night Tennessee Rivers
American Splendor
Departing from: Chattanooga, TennesseePorts of Call:- Decatur, Alabama
- Florence, Alabama
- Savannah, Tennessee
- Paducah, Kentucky
- Clarksville, Tennessee
- Nashville, Tennessee
Sailing Dates:- August 2025
interior fromNot Availableoceanview from$4,295$614pernightbalcony from$4,915$702pernightsuite from$6,800$971pernightAll the Cruise Line Offers & More:Riverview from $4,295($614pernight)4.1 rating out of 5 (4 reviews)
American Cruise Lines
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7 Night Lower Mississippi River
American Splendor
Departing from: New Orleans, LouisianaPorts of Call:- Houmas House Plantation, Louisiana
- Baton Rouge, Louisiana
- St. Francisville, Louisiana
- Natchez, Mississippi
- Vicksburg, Mississippi
- River Cruising
- Memphis, Tennessee
Sailing Dates:- February 2025
- March 2025
- April 2025
- May 2025
- June 2025
- July 2025
- November 2025
- February 2026
- March 2026
- April 2026
- May 2026
- June 2026
interior fromNot Availableoceanview from$3,895$556pernightbalcony from$4,515$645pernightsuite from$6,400$914pernightAll the Cruise Line Offers & More:Was $4,915 – Save up to 8%Riverview from $3,895($556pernight)4.1 rating out of 5 (4 reviews) -
7 Night Music Cities
American Splendor
Departing from: Nashville, TennesseePorts of Call:- Clarksville, Tennessee
- Dover, Tennessee
- River Cruising
- Paducah, Kentucky
- River Cruising
- Memphis, Tennessee
Sailing Dates:- June 2025
- July 2025
- September 2025
- October 2025
interior fromNot Availableoceanview from$3,795$542pernightbalcony from$4,415$631pernightsuite from$6,300$900pernightAll the Cruise Line Offers & More:Was $4,915 – Save up to 10%Riverview from $3,795($542pernight)4.1 rating out of 5 (4 reviews) -
7 Night The Tennessee Rivers
American Splendor
Departing from: Chattanooga, TennesseePorts of Call:- Decatur, Alabama
- Florence, Alabama
- Savannah, Tennessee
- Paducah, Kentucky
- River Cruising
- Nashville, Tennessee
Sailing Dates:- August 2026
- September 2026
interior fromNot Availableoceanview from$4,295$614pernightbalcony from$4,915$702pernightsuite from$6,800$971pernightAll the Cruise Line Offers & More:Riverview from $4,295($614pernight)4.1 rating out of 5 (4 reviews) -
7 Night Chesapeake Bay
American Independence
Departing from: Baltimore, MarylandPorts of Call:- Yorktown, Virginia
- Crisfield, Maryland
- Cambridge, Maryland
- St. Michaels, Maryland
- Annapolis, Maryland
Sailing Dates:- May 2025
- May 2026
interior fromNot Availableoceanview from$4,610$659pernightbalcony from$5,490$784pernightsuite from$7,295$1,042pernightAll the Cruise Line Offers & More:Riverview from $4,610($659pernight)4.6 rating out of 5 (8 reviews) -
7 Night Puget Sound & San Juan Islands
American Constellation
Departing from: Seattle, WashingtonPorts of Call:- Anacortes, Washington
- Friday Harbor, San Juan Island, Washington
- Cruise San Juan Islands
- Victoria, British Columbia
- Port Townsend, Washington
- Poulsbo, Washington
Sailing Dates:- April 2025
- May 2025
- September 2025
- October 2025
interior fromNot Availableoceanview from$4,700$671pernightbalcony from$5,465$781pernightsuite from$7,295$1,042pernightAll the Cruise Line Offers & More:Was $5,865 – Save up to 7%Riverview from $4,700($671pernight)4.9 rating out of 5 (7 reviews) -
7 Night Puget Sound & San Juan Islands
American Constitution
Departing from: Seattle, WashingtonPorts of Call:- Anacortes, Washington
- Friday Harbor, San Juan Island, Washington
- Victoria, British Columbia
- Port Townsend, Washington
- Poulsbo, Washington
Sailing Dates:- April 2025
- May 2025
- September 2025
- October 2025
- March 2026
- April 2026
- May 2026
- September 2026
- October 2026
interior fromNot Availableoceanview from$4,600$657pernightbalcony from$5,365$766pernightsuite from$7,295$1,042pernightAll the Cruise Line Offers & More:Was $5,865 – Save up to 9%Riverview from $4,600($657pernight)5 rating out of 5 (4 reviews) -
7 Night Lower Mississippi River
American Symphony
Departing from: New Orleans, LouisianaPorts of Call:- Houmas House Plantation, Louisiana
- Baton Rouge, Louisiana
- St. Francisville, Louisiana
- Natchez, Mississippi
- Vicksburg, Mississippi
- River Cruising
- Memphis, Tennessee
Sailing Dates:- July 2025
- September 2025
- April 2026
- July 2026
- September 2026
- November 2026
- December 2026
interior fromNot Availableoceanview fromNot Availablebalcony from$4,415$631pernightsuite from$6,300$900pernightAll the Cruise Line Offers & More:Was $4,915 – Save up to 10%Balcony from $4,415($631pernight)4.2 rating out of 5 (4 reviews) -
7 Night Lower Mississippi River
American Symphony
Departing from: Memphis, TennesseePorts of Call:- River Cruising
- Vicksburg, Mississippi
- Natchez, Mississippi
- St. Francisville, Louisiana
- Baton Rouge, Louisiana
- Houmas House Plantation, Louisiana
- New Orleans, Louisiana
Sailing Dates:- July 2025
- August 2025
- November 2025
- April 2026
- July 2026
- August 2026
- November 2026
- December 2026
interior fromNot Availableoceanview fromNot Availablebalcony from$4,415$631pernightsuite from$6,300$900pernightAll the Cruise Line Offers & More:Was $4,915 – Save up to 10%Balcony from $4,415($631pernight)4.2 rating out of 5 (4 reviews) -
7 Night Columbia & Snake Rivers
American Pride
Departing from: Portland, OregonPorts of Call:- Hayden Island, Portland, Oregon
- Astoria, Oregon
- Mount St. Helens, Washington
- Cruise Columbia River, Pacific Northwest, Usa
- The Dalles, Oregon
- Pendleton, Oregon
- Cruise Snake River, Pacific Northwest, Usa
- Clarkston, Washington
Sailing Dates:- April 2025
- May 2025
- June 2025
- July 2025
- August 2025
- September 2025
- October 2025
interior fromNot Availableoceanview from$4,840$691pernightbalcony from$5,595$799pernightsuite from$7,795$1,114pernightAll the Cruise Line Offers & More:Was $5,995 – Save up to 7%Riverview from $4,840($691pernight)4.4 rating out of 5 (7 reviews) -
7 Night Lower Mississippi River
American Melody
Departing from: Memphis, TennesseePorts of Call:- River Cruising
- Vicksburg, Mississippi
- Natchez, Mississippi
- St. Francisville, Louisiana
- Baton Rouge, Louisiana
- Houmas House Plantation, Louisiana
- New Orleans, Louisiana
Sailing Dates:- April 2025
- May 2025
- April 2026
- May 2026
- November 2026
interior fromNot Availableoceanview fromNot Availablebalcony from$5,275$754pernightsuite from$7,295$1,042pernightAll the Cruise Line Offers & More:Balcony from $5,275($754pernight)5 rating out of 5 (8 reviews) -
7 Night Upper Mississippi River
American Serenade
Departing from: St. Paul, MinnesotaPorts of Call:- Red Wing (Minneapolis), Minnesota
- Winona, Minnesota
- Dubuque, Iowa
- Davenport, Iowa
- Fort Madison, Iowa
- Hannibal, Missouri
- St. Louis, Missouri
Sailing Dates:- July 2025
- August 2025
- July 2026
- August 2026
interior fromNot Availableoceanview fromNot Availablebalcony from$5,135$734pernightsuite from$7,295$1,042pernightAll the Cruise Line Offers & More:Was $5,635 – Save up to 9%Balcony from $5,135($734pernight) -
7 Night Columbia & Snake Rivers
American Harmony
Departing from: Portland, OregonPorts of Call:- Hayden Island, Portland, Oregon
- Astoria, Oregon
- Mount St. Helens, Washington
- Cruise Columbia River, Pacific Northwest, Usa
- The Dalles, Oregon
- Pendleton, Oregon
- Cruise Snake River, Pacific Northwest, Usa
- Clarkston, Washington
Sailing Dates:- April 2025
- May 2025
- June 2025
- July 2025
- August 2025
- September 2025
- October 2025
- March 2026
- April 2026
- May 2026
- June 2026
- July 2026
- August 2026
- September 2026
- October 2026
interior fromNot Availableoceanview fromNot Availablebalcony from$5,495$785pernightsuite from$7,790$1,113pernightAll the Cruise Line Offers & More:Was $5,995 – Save up to 8%Balcony from $5,495($785pernight)5 rating out of 5 (6 reviews) -
7 Night Southeast Alaska
American Constellation
Departing from: Juneau, AlaskaPorts of Call:- Haines, Alaska
- Glacier Bay National Park, Alaska (Scenic Cruising)
- Petersburg, Alaska
- Cruise Wrangell Narrows, Alaska
- Wrangell, Alaska
- Cruise Tracy Arm Fjord, Alaska
Sailing Dates:- May 2025
- June 2025
- July 2025
- August 2025
- September 2025
- May 2026
- June 2026
- July 2026
- August 2026
- September 2026
interior fromNot Availableoceanview from$5,900$843pernightbalcony from$6,865$981pernightsuite from$9,280$1,326pernightAll the Cruise Line Offers & More:Was $7,365 – Save up to 7%Riverview from $5,900($843pernight)4.9 rating out of 5 (7 reviews) -
10 Night Alaskan Explorer
American Constellation
Departing from: Juneau, AlaskaPorts of Call:- Haines, Alaska
- Cruise Inside Passage, Alaska
- Glacier Bay National Park, Alaska (Scenic Cruising)
- Sitka, Alaska
- Wrangell, Alaska
- Cruise Wrangell Narrows, Alaska
- Petersburg, Alaska
- Cruise Inside Passage, Alaska
- Cruise Tracy Arm Fjord, Alaska
Sailing Dates:- June 2025
- July 2025
- August 2025
- June 2026
- July 2026
- August 2026
interior fromNot Availableoceanview from$8,525$853pernightbalcony from$9,915$992pernightsuite from$13,350$1,335pernightAll the Cruise Line Offers & More:Was $10,665 – Save up to 7%Riverview from $8,525($853pernight)4.9 rating out of 5 (7 reviews) -
14 Night Alaska Inside Passage
American Constellation
Departing from: Seattle, WashingtonPorts of Call:- Anacortes, Washington
- Friday Harbor, San Juan Island, Washington
- Cruise Queen Charlotte Sound, British Columbia
- Cruise Inside Passage, Alaska
- Ketchikan, Alaska
- Wrangell, Alaska
- Petersburg, Alaska
- Cruise Tracy Arm Fjord, Alaska
- Cruise Glacier Bay National Park
- Haines, Alaska
- Skagway, Alaska
- Juneau, Alaska
Sailing Dates:- May 2025
- May 2026
interior fromNot Availableoceanview from$9,810$701pernightbalcony from$11,435$817pernightsuite from$15,380$1,099pernightAll the Cruise Line Offers & More:Was $12,435 – Save up to 8%Riverview from $9,810($701pernight)4.9 rating out of 5 (7 reviews)
See the U.S. Like Never Before Aboard American Cruise Lines
Set sail on the adventure of a lifetime aboard a small cruise ship or riverboat with ample amenities and top-notch service delivered by an all-American crew. A relaxed, casual atmosphere combined with an unparalleled attention to detail will make you feel right at home from the beginning to the end of your journey.
New England itineraries take you to charming seaside towns and islands, cruising the coast from Newport, Rhode Island up to Bar Harbor, Maine. Dive into the area's rich maritime history and taste some of the nation's best seafood along the way.
Across the country to the West Coast, you'll find American Cruise Lines river and ocean sailings to take you through the Pacific Northwest and Alaska. Set out on the very same trail that Lewis and Clark once traversed, see pods of orcas swimming in the Puget Sound, or sample delicious wines in wine country. Each itinerary offers so much to explore.
Sailing the Mississippi is a unique adventure all its own. With river cruises spanning St. Louis, Missouri to St. Paul, Minnesota and Memphis, Tennessee to New Orleans, Louisiana, there's so much to do and see. Visit old plantations and Civil War battlefields, tour the hometown of Mark Twain, and indulge in blues and BBQ.
Experience southern hospitality at its finest aboard Southeast cruises navigating the Intracoastal Waterway and Chesapeake Bay. Historic landmarks and local treasures abound from the great rivers of Florida to the Golden Isles and beyond.
With exceptional cuisine, daily entertainment, and complimentary experiences, traveling aboard an American Cruise Lines world-class ship is a remarkable experience you'll never forget. Book now to begin your next adventure of the United States.